Dr. Grikscheit’s work is at the forefront of efforts in laboratories around the world to build replacement organs and tissues. Although the long-sought goal of creating complex organs like hearts and livers to ease transplant shortages remains a long way off, researchers are having success making simpler structures like bladders and windpipes, thanks to advances in understanding stem cells — basic cells that can be transformed into other types within the body — and to the development of innovative techniques.
So far Dr. Grikscheit has concentrated on growing rat, mouse and pig intestinal tissue in laboratory animals. But she has recently had success in growing human intestinal tissue, using donor cells, and is beginning to study how to develop the technique for human patients. There are many hurdles, and human testing is still years away, but she has a surgeon’s confidence that the technique will work.
“We have a huge problem that if we solve it, it will change the future for a lot of children,” she said.
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