Surprising culprits behind cell death from fat and sugar overload

Excess nutrients, such as fat and sugar, don't just pack on the pounds but can push some cells in the body over the brink. Unable to tolerate this "toxic" environment, these cells commit suicide.

Now, scientists at Washington University School of Medicine in St. Louis have discovered three unexpected players that help a cell overloaded with fat initiate its own demise. They have shown that these molecules leading a cell to self-destruct are not proteins as might be expected, but small strands of RNA, a close chemical cousin to DNA. Since these small nucleolar RNAs play well-known roles in building proteins, the researchers were surprised to implicate them in killing cells.

Surprising culprits behind cell death from fat and sugar overload