Scientists have found that calorie restriction -- a diet composed of approximately 30 percent fewer calories but with the same nutrients of a standard diet -- does not extend years of life or reduce age-related deaths in a 23-year study of rhesus monkeys. However, calorie restriction did extend certain aspects of health.
The research, conducted by scientists at the National Institute on Aging (NIA) at the National Institutes of Health, is reported in the August 29, 2012 online issue of Nature.
Calorie restriction research has a long history. The first finding came in the 1930s, when investigators observed laboratory rats and mice lived up to 40 percent longer when fed a calorie-restricted diet. Subsequent research has cited calorie restriction as extending lifespan of yeast, worms, flies and some strains of mice. But other studies have not shown a longevity benefit. For example, in studies of certain strains of mice, calorie restriction on average had no effect on lifespan. Some of these mice actually had a shorter lifespan when given a calorie-restricted diet. To date, research does not provide evidence that calorie restriction is an appropriate age regulator in humans, the NIA investigators point out. Currently, limited human studies are under way to test the effectiveness and safety of calorie restriction in people.
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